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New Light Chain Amyloid Response Criteria Help Risk Stratification of Patients by Day 100 after Autologous Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant 2016 Apr;22(4):768-770 PMID: 26743343 PMCID: PMC4801777

Pubmed ID

26743343

DOI

10.1016/j.bbmt.2015.12.021

Abstract

Hematologic response criteria in light chain (AL) amyloidosis were updated in 2012 to incorporate free light chain responses. These criteria have been validated in autologous hematopoietic cell transplantation in AL at 6 and 12 months after transplantation. Using a transplantation registry, we assessed day 100 responses in AL amyloidosis. We validate the prognostic significance of the new criteria at this time point. Further, we show that patients who do not achieve at least a very good partial response by this time point have equally worse outcomes, regardless of depth of response (partial versus no response). Thus, we conclude that the new criteria help identify the poor responders by day 100 after transplantation and that this subset of patients should be studied for early evaluation in consolidation trials.

Author List

D'Souza A, Huang J, Hari P

Authors

Anita D'Souza MD Assistant Professor in the Medicine department at Medical College of Wisconsin
Parameswaran Hari MD Chief, Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-84960472606   1 Citations

MESH terms used to index this publication - Major topics in bold

Adult
Aged
Amyloidosis
Biomarkers
Female
Hematopoietic Stem Cell Transplantation
Humans
Immunoglobulin Light Chains
Immunoglobulin Light-chain Amyloidosis
Male
Melphalan
Middle Aged
Myeloablative Agonists
Prognosis
Registries
Risk Assessment
Survival Analysis
Transplantation, Autologous
Treatment Outcome
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916