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Sleep deprivation in the rat: VII. Immune function. Sleep 1989 Feb;12(1):47-52

Date

02/01/1989

Pubmed ID

2784583

DOI

10.1093/sleep/12.1.47

Scopus ID

2-s2.0-0024496844   47 Citations

Abstract

Immune function studies were performed on splenic lymphocytes obtained from rats subjected to total or paradoxical sleep deprivation. Spleen cell counts, in vitro lymphocyte proliferation responses to mitogens, and in vitro and in vivo plaque-forming cell responses to antigens were obtained. Sleep-deprived rats were roughly equivalent to both their yoked controls and home-cage controls in all assays. The results do not support the hypothesis that sleep deprivation results in immune suppression as measured by the above-mentioned parameters.

Author List

Benca RM, Kushida CA, Everson CA, Kalski R, Bergmann BM, Rechtschaffen A

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Antibody Formation
B-Lymphocytes
Cerebral Cortex
Electroencephalography
Immune Tolerance
Lymphocyte Activation
Male
Rats
Rats, Inbred Strains
Sleep Deprivation
Sleep Stages
Sleep, REM
T-Lymphocytes
jenkins-FCD Prod-406 0f9a74600e4e79798f8fa6f545ea115f3dd948b2