The topography of callosal reading pathways. A case-control analysis. Brain 1992 Dec;115 ( Pt 6):1807-26
Date
12/01/1992Pubmed ID
1486462DOI
10.1093/brain/115.6.1807Scopus ID
2-s2.0-0027053688 (requires institutional sign-in at Scopus site) 212 CitationsAbstract
Lesion topography and reading ability were analysed in 17 patients with dominant posterior cerebral artery territory infarction. Patients with dominant posterior cerebral artery infarction in whom reading was unaffected served as an anatomical control group. Normal readers had lesions in the medial and ventral occipital lobe, sparing dorsal white matter pathways and the ventral temporal lobe. Global and permanent alexia occurred only with additional injury to the splenium, forceps major or white matter above the occipital horn of the lateral ventricle. These data suggest that callosal pathways mediating reading lie above the occipital horn and have little connection with the ventromedial occipital region. Patients with 'spelling dyslexia' had large lesions of the ventral temporal lobe involving cortical regions believed to participate in later stages of visual processing. These findings provide a framework for the prediction of dyslexia type and severity based on lesion topography.
Author List
Binder JR, Mohr JPAuthor
Jeffrey R. Binder MD Professor in the Neurology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Case-Control Studies
Cerebral Infarction
Corpus Callosum
Dyslexia
Dyslexia, Acquired
Female
Humans
Male
Middle Aged
Neural Pathways
Reading