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A prospective microstructure imaging study in mixed-martial artists using geometric measures and diffusion tensor imaging: methods and findings. Brain Imaging Behav 2017 Jun;11(3):698-711

Date

04/14/2016

Pubmed ID

27071950

Pubmed Central ID

PMC5889053

DOI

10.1007/s11682-016-9546-1

Scopus ID

2-s2.0-84963660243   9 Citations

Abstract

Although diffusion magnetic resonance imaging (dMRI) has been widely used to characterize the effects of repetitive mild traumatic brain injury (rmTBI), to date no studies have investigated how novel geometric models of microstructure relate to more typical diffusion tensor imaging (DTI) sequences. Moreover, few studies have evaluated the sensitivity of different registration pipelines (non-linear, linear and tract-based spatial statistics) for detecting dMRI abnormalities in clinical populations. Results from single-subject analyses in healthy controls (HC) indicated a strong negative relationship between fractional anisotropy (FA) and orientation dispersion index (ODI) in both white and gray matter. Equally important, only moderate relationships existed between all other estimates of free/intracellular water volume fractions and more traditional DTI metrics (FA, mean, axial and radial diffusivity). These findings suggest that geometric measures provide differential information about the cellular microstructure relative to traditional DTI measures. Results also suggest greater sensitivity for non-linear registration pipelines that maximize the anatomical information available in T-weighted images. Clinically, rmTBI resulted in a pattern of decreased FA and increased ODI, largely overlapping in space, in conjunction with increased intracellular and free water fractions, highlighting the potential role of edema following repeated head trauma. In summary, current results suggest that geometric models of diffusion can provide relatively unique information regarding potential mechanisms of pathology that contribute to long-term neurological damage.

Author List

Mayer AR, Ling JM, Dodd AB, Meier TB, Hanlon FM, Klimaj SD

Author

Timothy B. Meier PhD Associate Professor in the Neurosurgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Athletic Injuries
Brain
Brain Edema
Brain Injuries
Diffusion Magnetic Resonance Imaging
Diffusion Tensor Imaging
Female
Gray Matter
Humans
Male
Martial Arts
Neuropsychological Tests
Prospective Studies
Regression Analysis
Retrospective Studies
Self Report
White Matter
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