Vasopressin in cardiovascular patients: therapeutic implications. Expert Opin Pharmacother 2002 May;3(5):505-12
Date
05/09/2002Pubmed ID
11996629DOI
10.1517/14656566.3.5.505Scopus ID
2-s2.0-0036094077 (requires institutional sign-in at Scopus site) 10 CitationsAbstract
Vasopressin is a vital homeostatic protein which regulates fluid balance via its antidiuretic effects and vascular tone via its vasoconstrictive effects. Endogenous vasopressin deficiency has been implicated in several disease states resulting in vasodilatory shock. In particular, vasopressin levels are low in patients following cardiac surgery and in those with ventricular dysrhythmias. Several recent studies have demonstrated the effectiveness of exogenous vasopressin in providing haemodynamic support in patients with postcardiopulmonary bypass vasodilatory shock and refractory ventricular fibrillation. This manuscript reviews the pathophysiological and clinical basis for vasopressin replacement in patients with cardiovascular collapse.
Author List
Zimmerman MA, Albright TN, Raeburn CD, Selzman CHMESH terms used to index this publication - Major topics in bold
Cardiopulmonary ResuscitationCardiovascular Diseases
Deamino Arginine Vasopressin
Hemostatics
Humans
Postoperative Period
Vasopressins
