The case for beta-adrenergic blockade as prophylaxis against perioperative cardiovascular morbidity and mortality. Arch Surg 2001 Mar;136(3):286-90
Date
03/20/2001Pubmed ID
11231847DOI
10.1001/archsurg.136.3.286Scopus ID
2-s2.0-0035089638 (requires institutional sign-in at Scopus site) 36 CitationsAbstract
Perioperative morbidity and mortality are frequently cardiac in origin. Many studies have prospectively attempted to define risk factors for cardiac ischemic events. Although we can now identify high-risk patients, optimal cardioprotective management strategies remain unclear. Treatment with beta-adrenergic antagonists decreases myocardial oxygen consumption and is generally well tolerated. This article reviews the physiologic and clinical basis for using these agents as prophylaxis against cardiovascular events in high-risk surgical patients.
Author List
Selzman CH, Miller SA, Zimmerman MA, Harken AHMESH terms used to index this publication - Major topics in bold
Adrenergic beta-AntagonistsAnimals
Arrhythmias, Cardiac
Heart Failure
Humans
Myocardial Infarction
Myocardium
Oxygen Consumption
Postoperative Complications
Premedication
Randomized Controlled Trials as Topic
Survival Rate