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Voriconazole-induced blistering in the setting of graft versus host disease: A report of 2 patients. J Am Acad Dermatol 2008 Mar;58(3):484-7 PMID: 18280346

Pubmed ID

18280346

Abstract

Voriconazole is a newer triazole antifungal agent with a wide spectrum of activity against yeast, fungi and molds including many Candida, Aspergillus, and Fusarium species. Its use continues to increase, particularly in immunocompromised patients, owing to its broad coverage, availability in both intravenous and oral preparations, and safety profile. The detection of adverse events in these patients may be complicated by their preexisting comorbidities and polypharmacy. We describe 2 patients with hematologic malignancies status post allogeneic bone marrow transplantation who developed blistering eruptions on the extremities related to voriconazole use. A history of graft versus host disease in each patient confounded and delayed the diagnosis. It is imperative to recognize voriconazole-induced blistering as a separate and distinct entity in such patients with a history of graft versus host disease, since delayed withdrawal of voriconazole use could result in unnecessary and potentially dangerous increases in immunosuppressive therapy.

Author List

Conlon JD, Dauenhauer M, Tonkovic-Capin V, Talano J, Margolis D, Drolet BA, Fairley JA

Authors

Beth A. Drolet MD Professor in the Dermatology department at Medical College of Wisconsin
David A. Margolis MD Professor in the Pediatrics department at Medical College of Wisconsin
Julie-An M. Talano MD Professor in the Pediatrics department at Medical College of Wisconsin




Scopus

2-s2.0-38949186469   9 Citations

MESH terms used to index this publication - Major topics in bold

Adult
Antifungal Agents
Blister
Bone Marrow Transplantation
Extremities
Female
Fusarium
Graft vs Host Disease
Humans
Male
Middle Aged
Mycoses
Pyrimidines
Triazoles
Voriconazole
jenkins-FCD Prod-296 4db9d02597e0a2e889e230f853b641c12f1c3ee3