Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Anesthetic management of a parturient with Stiff person syndrome for urgent cesarean delivery. Int J Obstet Anesth 2016 Aug;27:85-8

Date

07/06/2016

Pubmed ID

27378710

DOI

10.1016/j.ijoa.2016.05.006

Abstract

Stiff person syndrome is a rare neurologic disorder with an estimated incidence of 1:1000000. The underlying pathophysiology is truncal and proximal limb muscle stiffness resulting from continuous co-contracture of agonist and antagonist muscle groups concomitant with superimposed episodic muscle spasms. Loss of gamma-aminobutyric acid-mediated inhibition creates chronic excitation manifested by tonic agonist-antagonist muscle contraction. To date, only three case reports referred indirectly to the anesthetic management of parturients with Stiff person syndrome. The authors describe their management of a parturient with Stiff person syndrome who underwent urgent cesarean delivery under epidural anesthesia.

Author List

Boettcher BT, Muravyea M, Kuo C, Drexler C, Pagel PS

Authors

Brent Boettcher DO Assistant Professor in the Anesthesiology department at Medical College of Wisconsin
Paul S. Pagel MD, PhD Professor in the Anesthesiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adult
Anesthesia, Epidural
Anesthesia, Obstetrical
Cesarean Section
Emergencies
Female
Humans
Pregnancy
Stiff-Person Syndrome
jenkins-FCD Prod-387 b0ced2662056320369de4e5cd5f21c218c03feb3