Cis-dichlorodiammineplatinum II-induced syndrome of inappropriate secretion of antidiuretic hormone. Cancer 1988 Feb 01;61(3):448-50
Date
02/01/1988Pubmed ID
2827877DOI
10.1002/1097-0142(19880201)61:3<448::aid-cncr2820610307>3.0.co;2-#Scopus ID
2-s2.0-0023856790 (requires institutional sign-in at Scopus site) 33 CitationsAbstract
A patient with glioblastoma multiforme developed hyponatremia. This was accompanied by decreased mental awareness and seizures following cis-dichlorodiammine platinum II (DDP) chemotherapy. Treatment with hypertonic saline, furosemide diuresis, and fluid restriction promptly restored the serum sodium and neurologic status to normal. Hyponatremia did not recur despite subsequent tumor progression and increased intracranial pressure. The clinical picture suggested a drug-induced syndrome of inappropriate secretion of antidiuretic hormone. Hyponatremia should be considered when seizures or mental changes occur in patients treated with DDP.
Author List
Ritch PSMESH terms used to index this publication - Major topics in bold
CisplatinFurosemide
Glioblastoma
Humans
Hyponatremia
Inappropriate ADH Syndrome
Male
Mental Disorders
Middle Aged
Seizures
Sodium Chloride