Characterization of melt-derived 45S5 and sol-gel-derived 58S bioactive glasses. J Biomed Mater Res 2001;58(6):734-40
Date
12/18/2001Pubmed ID
11745528DOI
10.1002/jbm.10026Scopus ID
2-s2.0-0035188531 (requires institutional sign-in at Scopus site) 350 CitationsAbstract
The ability of bioactive glasses to form a bond to living bone and also to stimulate bone-cell proliferation depends on the chemical composition and on the surface texture of the glasses. In this work, the differences in physical properties between the melt-derived 45S5 and sol-gel-derived 58S Bioglass powders of various particle-size ranges were studied. The powders were characterized for particle-size distribution by laser spectrometry, for specific surface area and porosity by nitrogen sorption analysis, and for morphological features by scanning electron microscopy. Melt-derived 45S5 powders exhibited a low-porosity texture with surface area in the range 0.15-2.7 m(2)/g. In contrast, the sol-gel-derived powders exhibited a highly mesoporous texture, with surface area in the range of 126.5-164.7 m(2)/g and a large fraction of 6-9 nm pore sizes. These differences in texture, as well as variations in chemical composition, account for significant changes in the resorption and in vivo responses.
Author List
Sepulveda P, Jones JR, Hench LLAuthor
Test W. User test user title in the Anesthesiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdsorptionBiocompatible Materials
Bone Substitutes
Ceramics
Gels
Glass
Hydrogen-Ion Concentration
Materials Testing
Microscopy, Electron, Scanning
Nitrogen
Particle Size
Porosity
Powders
Surface Properties
