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Trajectories of Quality of Life after Hematopoietic Cell Transplantation: Secondary Analysis of Blood and Marrow Transplant Clinical Trials Network 0902 Data. Biol Blood Marrow Transplant 2016 Nov;22(11):2077-2083

Date

08/20/2016

Pubmed ID

27538374

Pubmed Central ID

PMC5068568

DOI

10.1016/j.bbmt.2016.08.012

Scopus ID

2-s2.0-84992374659 (requires institutional sign-in at Scopus site)   13 Citations

Abstract

Quality of life is increasingly recognized as an important secondary endpoint of hematopoietic cell transplantation (HCT). The current study examined the extent to which attrition results in biased estimates of patient quality of life. The study also examined whether patients differ in terms of trajectories of quality of life in the first 6 months after transplantation. A secondary data analysis was conducted of 701 participants who enrolled in the Blood and Marrow Transplantation Clinical Trials Network 0902 trial. Participants completed the Medical Outcomes Study Short Form 36, a measure of quality of life, before undergoing transplantation and again 100 days and 180 days after transplantation. Results indicated that attrition resulted in slightly biased overestimates of quality of life but the amount of overestimation remained stable over time. Patients could be grouped into 3 distinct classes based on physical quality of life: (1) low and stable; (2) average and declining, then stable; and (3) average and stable. Four classes of patients emerged for mental quality of life: (1) low and stable; (2) average, improving, then stable; (3) higher than average (by almost 1 SD) and stable; and (4) average and stable. Taken together, these data provide a more comprehensive understanding of quality of life that can be used to educate HCT recipients and their caregivers.

Author List

Jim HSL, Sutton SK, Small BJ, Jacobsen PB, Wood WA, Knight JM, Majhail NS, Syrjala KL, Lee SJ

Author

Jennifer M. Knight MD, MS Associate Professor in the Psychiatry and Behavioral Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adolescent
Adult
Aged
Bias
Bone Marrow Transplantation
Female
Hematopoietic Stem Cell Transplantation
Humans
Male
Middle Aged
Quality of Life
Surveys and Questionnaires
Time Factors
Young Adult