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Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Adv Mater 2014 May 28;26(20):3253-7

Date

02/20/2014

Pubmed ID

24550068

Pubmed Central ID

PMC4146397

DOI

10.1002/adma.201304995

Scopus ID

2-s2.0-84901485098 (requires institutional sign-in at Scopus site)   24 Citations

Abstract

A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.

Author List

Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DE

Authors

Akiko Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acrylic Resins
Animals
Biocompatible Materials
Biomimetic Materials
Bone Morphogenetic Protein 4
Cell Differentiation
Hydrogels
Kidney
MSX1 Transcription Factor
Mice
Oligopeptides
PAX9 Transcription Factor
Paired Box Transcription Factors
Porosity
Temperature
Tissue Scaffolds
Tooth