Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Adv Mater 2014 May 28;26(20):3253-7
Date
02/20/2014Pubmed ID
24550068Pubmed Central ID
PMC4146397DOI
10.1002/adma.201304995Scopus ID
2-s2.0-84901485098 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
A biologically inspired thermoresponsive polymer has been developed that mechanically induces tooth differentiation in vitro and in vivo by promoting mesenchymal cell compaction as seen in each pore of the scaffold. This normally occurs during the physiological mesenchymal condensation response that triggers tooth formation in the embryo.
Author List
Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DEAuthors
Akiko Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinTadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Acrylic ResinsAnimals
Biocompatible Materials
Biomimetic Materials
Bone Morphogenetic Protein 4
Cell Differentiation
Hydrogels
Kidney
MSX1 Transcription Factor
Mice
Oligopeptides
PAX9 Transcription Factor
Paired Box Transcription Factors
Porosity
Temperature
Tissue Scaffolds
Tooth