Mechanobiology and developmental control. Annu Rev Cell Dev Biol 2013;29:27-61
Date
10/09/2013Pubmed ID
24099083DOI
10.1146/annurev-cellbio-101512-122340Scopus ID
2-s2.0-84904240136 (requires institutional sign-in at Scopus site) 314 CitationsAbstract
Morphogenesis is the remarkable process by which cells self-assemble into complex tissues and organs that exhibit specialized form and function during embryological development. Many of the genes and chemical cues that mediate tissue and organ formation have been identified; however, these signals alone are not sufficient to explain how tissues and organs are constructed that exhibit their unique material properties and three-dimensional forms. Here, we review work that has revealed the central role that physical forces and extracellular matrix mechanics play in the control of cell fate switching, pattern formation, and tissue development in the embryo and how these same mechanical signals contribute to tissue homeostasis and developmental control throughout adult life.
Author List
Mammoto T, Mammoto A, Ingber DEAuthors
Akiko Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinTadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBiomechanical Phenomena
Cytoskeleton
Embryonic Development
Extracellular Matrix
Gene Expression Regulation, Developmental
Humans
Morphogenesis
Signal Transduction
