A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume. J Clin Anesth 2001 Aug;13(5):370-3
Date
08/11/2001Pubmed ID
11498319DOI
10.1016/s0952-8180(01)00289-6Scopus ID
2-s2.0-0034906181 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
STUDY OBJECTIVE: To investigate whether oral omeprazole 20 mg decreases the risk of aspiration pneumonia in patients with gastric tube reconstruction.
DESIGN: Consecutive study.
SETTING: Operation room of cancer center.
PATIENTS: Thirteen patients with gastric tube reconstruction for esophageal cancer.
INTERVENTIONS: Oral omeprazole 20 mg was given the night before surgery. A rapid-sequence induction with cricoid pressure was employed for induction of anesthesia. After tracheal intubation, a nasogastric catheter was inserted into the gastric tube and the contents were aspirated.
MEASUREMENTS AND MAIN RESULTS: The pH and volume of the gastric contents were measured. The pH and volume of the gastric tube contents were 4.5 +/- 1.6 (range from 2.5 to 7.0) and 9.5 +/- 10.2 mL (range from 0 to 30 mL), respectively. Food residue was recognized in nine patients. There was no patient with a pH below 2.5 and a volume of 25 mL or greater.
CONCLUSIONS: Omeprazole 20 mg decreased the acidity and volume of the gastric tube contents and reduced the risk of aspiration pneumonia in patients with a gastric tube in place.
Author List
Yamanaka Y, Mammoto T, Kita T, Kishi YAuthor
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Anti-Ulcer Agents
Esophagus
Female
Gastric Acid
Humans
Hydrogen-Ion Concentration
Intubation, Gastrointestinal
Male
Middle Aged
Omeprazole
Pneumonia, Aspiration
Stomach