Oral clonidine reduces the requirement of prostaglandin E1 for induced hypotension. Can J Anaesth 1999 Nov;46(11):1043-7
Date
11/24/1999Pubmed ID
10566924DOI
10.1007/BF03013199Scopus ID
2-s2.0-0033428721 (requires institutional sign-in at Scopus site) 7 CitationsAbstract
PURPOSE: To determine the effects of preanesthetic oral clonidine on the dose of prostaglandin EI (PGEI) required to produce hypotension during anesthesia.
METHOD: Oral placebo, 75 microg or 150 microg clonidine were administered 60 min prior to induction of anesthesia. Anesthesia was maintained with O2:N2O (30:70) and isoflurane 1.0%. After hemodynamic stabilization, an infusion of prostaglandin EI was started (0.05 microg x kg(-1) x min(-1)) and the rate of infusion was adjusted to maintain mean arterial pressure (MAP) between 60-70 mm Hg during operation.
RESULTS: Duration of hypotension in placebo, 75 microg and 150 microg preanesthetic oral clonidine treated groups were 132+/-46, 117+/-37 and 129+/-56 min, respectively. The PGEI requirement in each group were 1563+/-180 (28.6+/-3.2), 594+/-197 (10.8+/-3.6) and 283+/-30 (5.5+/-3.6) microg (microg x kg(-1)), respectively. In addition, blood loss in each group were 1461+/-389, 805+/-240 and 931+/-40 ml, respectively.
CONCLUSION: Preanesthetic oral clonidine decreased the dose of PGEI required to produce hypotension, and decreased the blood loss during operation.
Author List
Murakami K, Mammoto T, Kita T, Imai Y, Mashimo T, Kirita T, Sugimura M, Kishi YAuthor
Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Administration, OralAdrenergic alpha-Agonists
Adult
Aged
Alprostadil
Blood Pressure
Clonidine
Female
Heart Rate
Humans
Hypotension, Controlled
Middle Aged