Faculty Collaboration Database

Interactions between neuronal histamine and halothane anesthesia in rats. J Neurochem 1997 Jul;69(1):406-11

Date

07/01/1997

Pubmed ID

9202335

DOI

10.1046/j.1471-4159.1997.69010406.x

Scopus ID

2-s2.0-0030968262 (requires institutional sign-in at Scopus site)   18 Citations

Abstract

Using an in vivo microdialysis method, we measured the release of histamine in the anterior hypothalamic area (AHy) of rats under several concentrations of halothane anesthesia (1, 0.5, and 0.2%). The release of histamine increased to 341 and 325% at halothane concentrations of 0.5 and 0.2%, compared with the basal level at anesthesia induced by 1% halothane. alpha-Fluoromethylhistidine (100 mg/kg i.v.), a specific and irreversible inhibitor of histidine decarboxylase, reduced the histamine release to <35% of the basal value at 1% halothane anesthesia in the AHy, and also decreased the anesthetic requirement for halothane, evaluated as the minimum alveolar concentration (MAC), by 26%. Furthermore, pyrilamine (20 mg/kg i.v.), a brain-penetrating H1 antagonist, and zolantidine (20 mg/kg i.v.), a brain-penetrating H2 antagonist, reduced the MAC for halothane by 28.5 and 16%, respectively. Although thioperamide (5 mg/kg i.v.), an antagonist of presynaptic H3 autoreceptor, induced an approximate twofold increase in the level of histamine release in conscious freely moving rats, the same dose of thioperamide had little effect on the release of histamine under 1% halothane anesthesia in the AHy. Furthermore, thioperamide did not change the anesthetic requirement (MAC) for halothane. The present findings indicate that halothane anesthesia inhibits the release of neuronal histamine and that histaminergic neuron activities change the anesthetic requirement (MAC) for halothane through H1 as well as H2 receptors.

Author List

Mammoto T, Yamamoto Y, Kagawa K, Hayashi Y, Mashimo T, Yoshiya I, Yamatodani A

Author

Tadanori Mammoto MD, PhD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Anesthetics, Inhalation
Animals
Benzothiazoles
Drug Interactions
Enzyme Inhibitors
Halothane
Histamine Antagonists
Histamine H1 Antagonists
Histamine H2 Antagonists
Histamine Release
Male
Methylhistidines
Microdialysis
Neurons
Phenoxypropanolamines
Piperidines
Pyrilamine
Rats
Rats, Sprague-Dawley
Thiazoles