Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity. Neuroscience 2008 Jun 02;153(4):963-74
Date
04/29/2008Pubmed ID
18440709Pubmed Central ID
PMC2587428DOI
10.1016/j.neuroscience.2008.03.042Scopus ID
2-s2.0-43949093760 (requires institutional sign-in at Scopus site) 135 CitationsAbstract
Parkinson's disease is a common progressive neurodegenerative disorder characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta. Mitochondrial dysfunction has been strongly implicated in the pathogenesis of Parkinson's disease. Thus, therapeutic approaches that improve mitochondrial function may prove to be beneficial. Previously, we have documented that near-infrared light via light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCN-induced apoptotic cell death. The current study tested our hypothesis that LED treatment can protect neurons from both rotenone- and MPP(+)-induced neurotoxicity. Primary cultures of postnatal rat striatal and cortical neurons served as models, and the optimal frequency of LED treatment per day was also determined. Results indicated that LED treatments twice a day significantly increased cellular adenosine triphosphate content, decreased the number of neurons undergoing cell death, and significantly reduced the expressions of reactive oxygen species and reactive nitrogen species in rotenone- or MPP(+)-exposed neurons as compared with untreated ones. These results strongly suggest that LED treatment may be therapeutic to neurons damaged by neurotoxins linked to Parkinson's disease by energizing the cells and increasing their viability.
Author List
Liang HL, Whelan HT, Eells JT, Wong-Riley MTAuthor
Janis Eells PhD Professor in the Biomedical Sciences department at University of Wisconsin - MilwaukeeMESH terms used to index this publication - Major topics in bold
1-Methyl-4-phenylpyridiniumAdenosine Triphosphate
Analysis of Variance
Animals
Animals, Newborn
Cell Death
Cells, Cultured
Cerebral Cortex
Cyanates
Dose-Response Relationship, Radiation
Electron Transport Complex IV
Infrared Rays
Lasers, Semiconductor
Male
Neurons
Neurotoxins
Nitric Oxide
Rats
Rats, Sprague-Dawley
Reactive Oxygen Species
Rotenone
Tyrosine
