Estimates of nasal airflow at the nasal cycle mid-point improve the correlation between objective and subjective measures of nasal patency. Respir Physiol Neurobiol 2017 Apr;238:23-32
Date
01/17/2017Pubmed ID
28089607Pubmed Central ID
PMC5316304DOI
10.1016/j.resp.2017.01.004Scopus ID
2-s2.0-85009224928 (requires institutional sign-in at Scopus site) 29 CitationsAbstract
INTRODUCTION: The nasal cycle represents a significant challenge when comparing pre- and post-surgery objective measures of nasal airflow.
METHODS: Computational fluid dynamics (CFD) simulations of nasal airflow were conducted in 12 nasal airway obstruction patients showing significant nasal cycling between pre- and post-surgery computed tomography scans. To correct for the nasal cycle, mid-cycle models were created virtually. Subjective scores of nasal patency were obtained via the Nasal Obstruction Symptom Evaluation (NOSE) and unilateral visual analog scale (VAS).
RESULTS: The correlation between objective and subjective measures of nasal patency increased after correcting for the nasal cycle. In contrast to biophysical variables in individual patients, cohort averages were not significantly affected by the nasal cycle correction.
CONCLUSIONS: The ability to correct for the confounding effect of the nasal cycle is a key element that future virtual surgery planning software for nasal airway obstruction will need to account for when using anatomic models based on single instantaneous imaging.
Author List
Gaberino C, Rhee JS, Garcia GJAuthors
Guilherme Garcia PhD Assistant Professor in the Biomedical Engineering department at Medical College of WisconsinJohn S. Rhee MD Chair, Professor in the Otolaryngology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
Airway ResistanceBiophysics
Computational Biology
Computer Simulation
Female
Humans
Hydrodynamics
Imaging, Three-Dimensional
Male
Minimally Invasive Surgical Procedures
Models, Biological
Nasal Mucosa
Nasal Obstruction
Pulmonary Ventilation
Statistics as Topic
Tomography Scanners, X-Ray Computed
Treatment Outcome
Visual Analog Scale