Morphine initiates migrating myoelectric complexes by acting on peripheral opioid receptors. Am J Physiol 1985 Nov;249(5 Pt 1):G557-62
Date
11/01/1985Pubmed ID
2998200DOI
10.1152/ajpgi.1985.249.5.G557Scopus ID
2-s2.0-0022149367 (requires institutional sign-in at Scopus site) 24 CitationsAbstract
The role of peripheral and central opioid receptors in morphine-induced migrating myoelectric complexes (MMECs) was studied in conscious dogs implanted with silver-silver chloride electrodes. In normal fasted dogs morphine (100-200 micrograms/kg iv) initiated phase III of the MMEC in the duodenum. Once initiated the MMEC propagated distally. This effect of morphine was blocked by the opioid receptor antagonists naloxone (2 mg/kg iv) and N,N-diallylnormorphinium bromide (4 mg/kg iv). Higher doses of morphine (300-600 micrograms/kg iv) initiated phase III activity in fed dogs as early as 20 min after feeding, while lower doses (150 micrograms/kg iv) initiated phase III activity routinely when administered 100 min after feeding. In dogs with bilateral vagotomies and bilateral thoracolumbar sympathetic chain ganglionectomies, morphine (150 micrograms/kg iv) initiated phase III activity in the duodenum, which then migrated distally. This study demonstrates that morphine initiates phase III of the MMEC by acting through peripheral opioid receptors.
Author List
Telford GL, Hoshmonai M, Moses AJ, Szurszewski JHMESH terms used to index this publication - Major topics in bold
AnimalsBiomechanical Phenomena
Denervation
Digestive System
Dogs
Eating
Electrophysiology
Fasting
Gastrointestinal Motility
Intestine, Small
Morphine
Receptors, Opioid
Stomach
