Calibrating the photo-thermal response of magneto-fluorescent gold nanoshells. Annu Int Conf IEEE Eng Med Biol Soc 2011;2011:4776-9
Date
01/19/2012Pubmed ID
22255406DOI
10.1109/IEMBS.2011.6091183Scopus ID
2-s2.0-84863603066 (requires institutional sign-in at Scopus site) 1 CitationAbstract
We report the photothermal response and Near Infrared (NIR) imaging sensitivities of magneto-fluorescent silica core gold nanocomplexes designed for molecular image guided thermal therapy of cancer. Approximately 160 nm Silica core gold nanoshells were designed to provide NIR fluorescent and Magnetic Resonance (MR) contrast by incorporating FDA approved dye indocyanine green (ICG) and iron-oxide within an outer silica epilayer. The imaging and therapeutic sensitivity, and the stability of fluorescence contrast for 12 microliters of suspension (containing approximately 7.9 × 10(8) or 1.3 femtoMole nanoshells) buried at depths of 2-8 mm in tissue mimicking scattering media is reported.
Author List
Biswal NC, Ayala-Orzoco C, Halas NJ, Joshi AAuthor
Amit Joshi PhD Professor in the Biomedical Engineering department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
CalibrationFerric Compounds
Fluorescence
Gold
Indocyanine Green
Magnetic Resonance Spectroscopy
Magnetics
Nanostructures