Academic Cancer Center Phase I Program Development. Oncologist 2017 Apr;22(4):369-374
Date
03/21/2017Pubmed ID
28314841Pubmed Central ID
PMC5388388DOI
10.1634/theoncologist.2016-0409Scopus ID
2-s2.0-85017435066 (requires institutional sign-in at Scopus site)Abstract
Multiple factors critical to the effectiveness of academic phase I cancer programs were assessed among 16 academic centers in the U.S. Successful cancer centers were defined as having broad phase I and I/II clinical trial portfolios, multiple investigator-initiated studies, and correlative science. The most significant elements were institutional philanthropic support, experienced clinical research managers, robust institutional basic research, institutional administrative efforts to reduce bureaucratic regulatory delays, phase I navigators to inform patients and physicians of new studies, and a large cancer center patient base. New programs may benefit from a separate stand-alone operation, but mature phase I programs work well when many of the activities are transferred to disease-oriented teams. The metrics may be useful as a rubric for new and established academic phase I programs. The Oncologist 2017;22:369-374.
Author List
Frankel AE, Flaherty KT, Weiner GJ, Chen R, Azad NS, Pishvaian MJ, Thompson JA, Taylor MH, Mahadevan D, Lockhart AC, Vaishampayan UN, Berlin JD, Smith DC, Sarantopoulos J, Riese M, Saleh MN, Ahn C, Frenkel EPMESH terms used to index this publication - Major topics in bold
Academic Medical CentersClinical Trials as Topic
Humans
Neoplasms
Program Development
United States