Antibiotic-resistant pneumococci. Pediatr Clin North Am 1995 Jun;42(3):519-37
Date
06/01/1995Pubmed ID
7761139DOI
10.1016/s0031-3955(16)38977-5Scopus ID
2-s2.0-0029029032 (requires institutional sign-in at Scopus site) 63 CitationsAbstract
Antibiotic-resistant pneumococci are increasing in prevalence in the United States and are present in numerous areas of the country. Simple screening methods available to identify penicillin-resistant strains and improved national surveillance programs should give more accurate data on the frequency that these resistant pneumococci are causing disease. It is logical to assume that, as the prevalence of nasopharyngeal carriage of these strains increases, more and more invasive infections in children will be caused by antibiotic-resistant pneumococci in the future. The treatment of invasive infections, particularly meningitis, caused by penicillin-resistant and multiply resistant strains, and the treatment of AOM caused by pneumococci resistant to all currently available oral preparations remains problematic. Controlled studies are necessary to determine optimal antimicrobials or other interventions necessary to treat these infections. Finally, prevention of colonization and subsequent infection by the pneumococcus assumes new urgency as antimicrobial resistance spreads. Potentially effective vaccines, such as the new polysaccharide-protein conjugate vaccines that will have efficacy in small children, are currently in early field trials and ultimately may be the best mechanism to deal with the spread of these organisms.
Author List
Schreiber JR, Jacobs MRMESH terms used to index this publication - Major topics in bold
Anti-Bacterial AgentsChild
Drug Resistance, Microbial
Global Health
Humans
Meningitis, Pneumococcal
Penicillin Resistance
Pneumococcal Infections
Streptococcus pneumoniae