Faculty Collaboration Database

Effect of complement depletion on anticapsular-antibody-mediated immunity to experimental infection with Haemophilus influenzae type b. Infect Immun 1987 Nov;55(11):2830-3

Date

11/01/1987

Pubmed ID

3499398

Pubmed Central ID

PMC259984

DOI

10.1128/iai.55.11.2830-2833.1987

Scopus ID

2-s2.0-0023615634 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

Antibody to the capsular polysaccharide of Haemophilus influenzae type b (Hib) was not protective in infant rats depleted of complement by cobra venom factor (CoVF) even when serum antibody levels were many times the minimum protective level. Partial protection from Hib infection was achieved in CoVF-treated rats only if they were passively hyperimmunized with large doses of immunoglobulin G Hib capsular polysaccharide antibody. In addition, nonimmune CoVF-treated rats had higher mortality and blood bacterial density than nonimmune rats with intact complement systems.

Author List

Schreiber JR, Basker CJ, Siber GR

MESH terms used to index this publication - Major topics in bold

Animals
Animals, Newborn
Antibodies, Bacterial
Complement System Proteins
Haemophilus Infections
Haemophilus influenzae
Immunization, Passive
Immunoglobulin G
Polysaccharides, Bacterial
Rats