A pooled analysis of posttransplant survival following combined heart-liver transplantation. Transplantation 2007 Jan 15;83(1):95-8
Date
01/16/2007Pubmed ID
17220801DOI
10.1097/01.tp.0000243731.29657.87Scopus ID
2-s2.0-33846192386 (requires institutional sign-in at Scopus site) 23 CitationsAbstract
Because no single center has accumulated a large experience with this complex operation, the effectiveness of combined orthotopic heart transplantation (OHT) and orthotopic liver transplantation (OLT) in achieving long-term survival has been unknown. Cases of OHT-OLT were pooled from a U.S. transplant recipient registry and from previously published literature. Aggregate data from these sources was used for survival analysis. Thirty-six patients having undergone OHT-OLT were listed in the national registry; the one- and five-year patient survival rates of these patients were 88% and 78%, respectively. Many patients remain alive at 8+ years after transplantation. An analysis of the pooled results of previously-published cases estimated a one-year patient survival rate of 84%. In selected disease processes, OHT-OLT can correct underlying metabolic deficiencies. While rarely indicated, OHT-OLT is a successful treatment for patients with end-stage heart and liver disease, with survival comparable to that seen after isolated orthotopic heart or orthotopic liver transplantation.
Author List
Barshes NR, Udell IW, Joyce DL, Southard RE, O'Mahony CA, Goss JAMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Child
Child, Preschool
Female
Heart Transplantation
Humans
Liver Transplantation
Male
Middle Aged
Retrospective Studies
Survival Analysis
Survivors
Treatment Outcome
