Faculty Collaboration Database

The antiherpesvirus activity and cytotoxicity of sangivamycin. Curr Eye Res 1987 Jan;6(1):255-7

Date

01/01/1987

Pubmed ID

3030647

DOI

10.3109/02713688709020100

Scopus ID

2-s2.0-0023103671 (requires institutional sign-in at Scopus site)   2 Citations

Abstract

Sangivamycin, 4-amino-5-carboxamido-7-(beta-D-ribofuranosyl)-pyrrolo[2,3-d]-pyrimidine is a structural analog of adenosine belonging to a group of nucleosides classified as pyrrolopyrimidines. Sangivamycin, an adenosine deaminase resistant analog, was found to inhibit the replication of three strains of herpes simplex virus type 1 (HSV-1) by 50% (ED50) at a concentration approximately equal to the concentration which inhibits cell growth by 50% (LD50). Both Vero cells and rabbit corneal stromal cells in exponential growth were about 10-fold more sensitive to the drug than quiescent cells. The selectivity indices of sangivamycin indicated that the drug was not a highly selective antiviral agent and, therefore, would offer no advantage over drugs currently available for the treatment of herpetic keratitis.

Author List

O'Brien WJ, Taylor JL, O'Malley TP, Ritch PS

MESH terms used to index this publication - Major topics in bold

Animals
Cell Survival
Corneal Stroma
Keratitis, Dendritic
Pyrimidine Nucleosides
Rabbits
Simplexvirus
Vero Cells
Virus Replication