Faculty Collaboration Database

Attentional bias to smoking and other motivationally relevant cues is affected by nicotine exposure and dose expectancy. J Psychopharmacol 2016 Jul;30(7):627-40

Date

04/22/2016

Pubmed ID

27097731

Pubmed Central ID

PMC5858186

DOI

10.1177/0269881116642879

Scopus ID

2-s2.0-84975472335 (requires institutional sign-in at Scopus site)   10 Citations

Abstract

We investigated the effects of acute nicotine dose and expected dose on attentional bias (AB) to smoking and affective cues in overnight nicotine-deprived smokers (n=51; 24 women) using a balanced placebo design, which counterbalanced given nicotine dose (Given-NIC vs. Given-DENIC) with instructed nicotine dose expectancy (Told-NIC vs. Told-DENIC). Before and after smoking a study cigarette, smokers completed a vigilance task where they pressed buttons to every third consecutive even or odd digit, while ignoring intermittent smoking, pleasant, unpleasant, and neutral picture distracters. We examined the early posterior negativity (EPN) and late positive potential (LPP) components of the event-related potentials (ERPs) to the distracters, reaction time (RT) to the target digits, and ratings of the study cigarettes. The EPN was sensitive to both given and instructed nicotine dose, while the instructed dose moderated the impact of given dose for the LPP. The RT metrics were sensitive to given but not to instructed dose. The effects of given dose on ratings following cigarette smoking (e.g. enjoyment) were moderated by the instructed dose. The ERP findings suggest that the anticipated effects of nicotine improve attention much like receiving actual nicotine.

Author List

Robinson JD, Versace F, Engelmann JM, Cui Y, Gilbert DG, Waters AJ, Gritz ER, Cinciripini PM

MESH terms used to index this publication - Major topics in bold

Adult
Attention
Attentional Bias
Cues
Emotions
Evoked Potentials
Female
Humans
Male
Motivation
Nicotine
Reaction Time
Smoking
Tobacco Smoking