Predictive value of bronchiolitis obliterans syndrome stage 0p in chronic graft-versus-host disease of the lung. Biol Blood Marrow Transplant 2015 Jun;21(6):1127-31
Date
02/18/2015Pubmed ID
25687798Pubmed Central ID
PMC4970454DOI
10.1016/j.bbmt.2015.02.006Scopus ID
2-s2.0-84947490863 (requires institutional sign-in at Scopus site) 40 CitationsAbstract
Bronchiolitis obliterans syndrome (BOS) is a significant post-transplant complication with low survival. BOS stage 0p (BOS 0p) is a parameter detected on pulmonary function tests (PFTs) after lung transplantation to identify patients at risk to develop BOS. We performed a retrospective study on 442 patients who underwent allogeneic stem cell transplant from 2007 to 2011 to evaluate whether development of BOS 0p is a risk factor in this population for BOS. Patients who met criteria for BOS 0p were significantly more likely to develop BOS (hazard ratio [HR], 3.22; P < .001). BOS 0p was significantly associated with a history of lung disease pretransplant (HR, 2.48; P = .001) and chronic graft-versus-host disease (GVHD) outside the lung post-transplant (HR, 23; P < .001). Finally, BOS 0p criteria were adequately sensitive in predicting BOS (85%), with a high negative predictive value (98%). Our findings suggest a routine PFT screening strategy with the intent of detecting BOS 0p, especially among patients with prior lung disease and who developed chronic GVHD, could suitably identify an at-risk population for the development of BOS.
Author List
Abedin S, Yanik GA, Braun T, Pawarode A, Magenau J, Goldstein SC, Levine JE, Kitko CL, Couriel DRAuthor
Sameem Abedin MD Associate Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdolescentAdult
Aged
Bronchiolitis Obliterans
Female
Graft vs Host Disease
Hematopoietic Stem Cell Transplantation
Humans
Lung
Lung Transplantation
Male
Middle Aged
Multivariate Analysis
Myeloablative Agonists
Predictive Value of Tests
Prognosis
Respiratory Function Tests
Retrospective Studies
Risk Factors
Siblings
Survival Analysis
Transplantation Conditioning
Transplantation, Homologous
Unrelated Donors
