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The New Realization About Cribriform Prostate Cancer. Adv Anat Pathol 2018 Jan;25(1):31-37

Date

08/19/2017

Pubmed ID

28820750

DOI

10.1097/PAP.0000000000000168

Scopus ID

2-s2.0-85038253514   19 Citations

Abstract

Data from the past 6 years have shown that the presence of any amount of cribriform (or more comprehensively, large acinar cribriform to papillary) pattern of invasive prostate cancer is associated with adverse pathologic features and leads to uniquely adverse outcomes. Sixteen papers and numerous abstracts have reached these conclusions concordantly. Not only does this justify removal of all cribriform cancer from Gleason grade 3, it shows that cribriform cancer has pathologic, outcome, and molecular features distinct from noncribriform Gleason grade 4. Suggestions for accommodating the presence of cribriform cancer into the 2014 Grade Group scheme are proposed.

Author List

Iczkowski KA, Paner GP, Van der Kwast T

Author

Kenneth A. Iczkowski MD Professor in the Pathology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Biomarkers, Tumor
Biopsy
Humans
Male
Neoplasm Grading
Predictive Value of Tests
Prostatic Neoplasms
jenkins-FCD Prod-411 e00897e83867fcfa48419861683711f8d99adb75