DNA content in radiation-associated thyroid cancer. Surgery 1988 Dec;104(6):992-6
Date
12/01/1988Pubmed ID
3194850Scopus ID
2-s2.0-0024246984 (requires institutional sign-in at Scopus site) 3 CitationsAbstract
DNA content has been reported to be of prognostic significance in differentiated thyroid carcinoma. Since malignant tumors with irradiation as an initiator often contain DNA aberrations, the DNA content of well-differentiated thyroid carcinoma in patients with a prior history of low-dose head and neck irradiation was determined and compared with similar nonradiation-associated lesions. The DNA content of thyroid cancers from 53 patients was determined with use of flow cytometry. Sixteen radiation-associated thyroid carcinomas (11 papillary, 3 follicular, and 2 medullary) all were diploid. In a group of 37 nonradiation-associated tumors, 10 were aneuploid (10 of 29 papillary carcinomas and 0 of 2 follicular or 6 medullary carcinomas). This difference in DNA content is significant (p less than 0.02, Fisher's exact test). These findings were unexpected and suggest that if the initiating irradiation causes a DNA aberration, this aberration is not reflected in DNA content as measured by means of flow cytometry.
Author List
Komorowski RA, Deaconson TF, Vetsch R, Cerletty JM, Wilson SDMESH terms used to index this publication - Major topics in bold
AdenocarcinomaAdult
Aneuploidy
Carcinoma
Carcinoma, Papillary
DNA
Female
Humans
Lymphatic Metastasis
Male
Neoplasms, Radiation-Induced
Thyroid Neoplasms
Thyroidectomy
