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The endo-lysosomal system as an NAADP-sensitive acidic Ca(2+) store: role for the two-pore channels. Cell Calcium 2011 Aug;50(2):157-67 PMID: 21529939 PMCID: PMC3160778

Abstract

Accumulating evidence suggests that the endo-lysosomal system provides a substantial store of Ca(2+) that is tapped by the Ca(2+)-mobilizing messenger, NAADP. In this article, we review evidence that NAADP-mediated Ca(2+) release from this acidic Ca(2+) store proceeds through activation of the newly described two-pore channels (TPCs). We discuss recent advances in defining the sub-cellular targeting, topology and biophysics of TPCs. We also discuss physiological roles and the evolution of this ubiquitous ion channel family.

Author List

Patel S, Ramakrishnan L, Rahman T, Hamdoun A, Marchant JS, Taylor CW, Brailoiu E

Author

Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Acids
Animals
Calcium
Calcium Channels
Cell Membrane
Endosomes
Humans
Ion Channel Gating
Lysosomes
NADP
Potassium Channels, Voltage-Gated
Sodium Channels
Sodium-Calcium Exchanger



View this publication's entry at the Pubmed website PMID: 21529939
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