Localization and socialization: experimental insights into the functional architecture of IP3 receptors. Chaos 2009 Sep;19(3):037103
Date
10/02/2009Pubmed ID
19792028Pubmed Central ID
PMC2771704DOI
10.1063/1.3147425Scopus ID
2-s2.0-70349634912 (requires institutional sign-in at Scopus site) 13 CitationsAbstract
Inositol 1,4,5-trisphosphate (IP(3))-evoked Ca(2+) signals display great spatiotemporal malleability. This malleability depends on diversity in both the cellular organization and in situ functionality of IP(3) receptors (IP(3)Rs) that regulate Ca(2+) release from the endoplasmic reticulum (ER). Recent experimental data imply that these considerations are not independent, such that-as with other ion channels-the local organization of IP(3)Rs impacts their functionality, and reciprocally IP(3)R activity impacts their organization within native ER membranes. Here, we (i) review experimental data that lead to our understanding of the "functional architecture" of IP(3)Rs within the ER, (ii) propose an updated terminology to span the organizational hierarchy of IP(3)Rs observed in intact cells, and (iii) speculate on the physiological significance of IP(3)R socialization in Ca(2+) dynamics, and consequently the emerging need for modeling studies to move beyond gridded, planar, and static simulations of IP(3)R clustering even over short experimental timescales.
Author List
Diambra L, Marchant JSAuthor
Jonathan S. Marchant PhD Chair, Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AlgorithmsAnimals
Biological Clocks
Calcium Signaling
Computer Simulation
Humans
Inositol 1,4,5-Trisphosphate Receptors
Ion Channel Gating
Models, Biological
Nonlinear Dynamics
Oscillometry
Subcellular Fractions