Fatal rhabdomyolysis following influenza infection in a girl with familial carnitine palmityl transferase deficiency. Pediatrics 1989 Aug;84(2):312-6
Date
08/01/1989Pubmed ID
2748260Scopus ID
2-s2.0-0024412724 (requires institutional sign-in at Scopus site) 54 CitationsAbstract
Severe rhabdomyolysis following an influenza B infection developed in a previously well 13-year-old girl. There was no history of trauma. Her course was complicated by episodes of severe hyperkalemia, hypocalcemia, hyperphosphatemia, and myoglobinuria. Renal failure, hypertension, and life-threatening arrhythmias developed; she died. Muscle biopsy revealed that this girl had carnitine palmityl transferase deficiency. An asymptomatic sister was demonstrated to have the same disorder. Although carnitine palmityl transferase deficiency is usually associated with mild bouts of rhabdomyolysis that become apparent only in adulthood, severe forms of this disorder may be seen in children. Life-threatening rhabdomyolysis and myoglobinuria may follow any infection associated with decreased intake. If carnitine palmityl transferase deficiency is diagnosed in a proband, other siblings should be evaluated so that proper preventative measures can be undertaken to help prevent the development of symptoms in susceptible individuals who have not been recognized to have the disease.
Author List
Kelly KJ, Garland JS, Tang TT, Shug AL, Chusid MJMESH terms used to index this publication - Major topics in bold
Acute Kidney InjuryAcyltransferases
Adolescent
Carnitine O-Palmitoyltransferase
Female
Humans
Influenza B virus
Influenza, Human
Muscles
Myoglobinuria
Rhabdomyolysis