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Natural supplements for improving insulin sensitivity and glucose uptake in skeletal muscle. Front Biosci (Elite Ed) 2015 Jan 01;7:94-106 PMID: 25553366


Type 2 diabetes is a common metabolic disorder characterized by resistance to the actions of insulin to stimulate skeletal muscle glucose disposal. In light of the staggering financial/human cost of type 2 diabetes, there is considerable need for safe and effective agents that can be used to prevent and/or adjunctively treat the disease. Available evidence suggests that a number of natural supplements, including cinnamon, biotin, fenugreek, ginseng, banaba, and alpha-lipoic acid, have the potential to reduce the risk for type 2 diabetes in the large at-risk population. The evidence also suggests that, when used adjunctively, these natural products are likely to help clinicians achieve optimal glycemic control, improve long-term prognosis, and/or minimize the need for insulin therapy in type 2 diabetics. More research, particularly well-designed, long-term human clinical trials, is certainly needed to accurately define the value and place of these supplements in diabetes prevention and management.

Author List

Kouzi SA, Yang S, Nuzum DS, Dirks-Naylor AJ

MESH terms used to index this publication - Major topics in bold

Cinnamomum zeylanicum
Diabetes Mellitus, Type 2
Dietary Supplements
Insulin Resistance
Muscle, Skeletal
Plant Extracts
Thioctic Acid

View this publication's entry at the Pubmed website PMID: 25553366
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