Cerebral infarction in Hemophilus influenzae type B meningitis. Clin Pediatr (Phila) 1986 Apr;25(4):177-80
Date
04/01/1986Pubmed ID
3485026DOI
10.1177/000992288602500401Scopus ID
2-s2.0-0022633581 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
Over a 5-year period, 8 (4.7%) of the 170 children diagnosed at Milwaukee Children's Hospital as having Hemophilus influenzae type b (HITB) meningitis developed cerebral infarction. Compared with children who did not develop infarcts or with children who developed other neurologic complications, such as subdural effusion, empyema, or meningoencephalitis, these children had significantly higher cerebrospinal fluid (CSF) leukocyte counts on initial lumbar puncture and had a greater likelihood of seizure activity. In seven of eight patients with cerebral infarction, a focal or generalized seizure heralded neurologic findings associated with abnormal radiographic studies. Two of the eight patients died, and two were permanently severely damaged. In the other four patients, there was eventual recovery from gross neurologic deficits. The mortality in patients with HITB meningitis complicated by cerebral infarction (25%) was significantly greater than that in other patients with HITB meningitis (0.6%). The pathophysiology of infarction in patients with bacterial meningitis is uncertain but may in part relate to arteriospasm. Cerebral infarction is a serious, and in the present experience, not uncommon complication of H. influenzae meningitis.
Author List
Taft TA, Chusid MJ, Sty JRMESH terms used to index this publication - Major topics in bold
Cerebral InfarctionCerebrospinal Fluid Proteins
Child, Preschool
Female
Glucose
Haemophilus influenzae
Humans
Infant
Male
Medical Records
Meningitis, Haemophilus
Nervous System Diseases
Prognosis
Seizures