Faculty Collaboration Database

Pancreatic endocrine insufficiency in posttransplant cystinosis. Am J Dis Child 1987 Oct;141(10):1087-9

Date

10/01/1987

Pubmed ID

3307383

DOI

10.1001/archpedi.1987.04460100065027

Scopus ID

2-s2.0-0023573885 (requires institutional sign-in at Scopus site)   77 Citations

Abstract

Nephropathic cystinosis causes renal death by approximately age 10 years. With increased life span due to kidney transplantation, ten to 25 years of cystine accumulation has resulted in pancreatic complications in individuals with cystinosis. We noted severe hyperglycemia in five posttransplant patients, three of whom remained insulin-dependent diabetics several years after transplant. The clinical findings were not consistent with steroid-dependent or insulin-resistant diabetes. Pancreatic cystine deposition was detected histologically and biochemically on post-mortem examination of two other patients. We conclude that hyperglycemia may be anticipated in the immediate posttransplant period in cystinotic patients and that some patients will require insulin therapy years later. The use of cystine-depleting agents should be considered in posttransplant cystinosis as an attempt to prevent potential damage to the pancreas and other organs from cystine deposition.

Author List

Fivush B, Green OC, Porter CC, Balfe JW, O'Regan S, Gahl WA

MESH terms used to index this publication - Major topics in bold

Adolescent
Child
Cystinosis
Diabetes Mellitus, Type 1
Exocrine Pancreatic Insufficiency
Female
Humans
Kidney Diseases
Kidney Transplantation