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Measuring ventilatory acclimatization to hypoxia: comparative aspects. Respir Physiol 2000 Sep;122(2-3):271-84 PMID: 10967350

Pubmed ID



Acclimatization to hypoxia increases the hypoxic ventilatory response (HVR) in mammals. The literature on humans shows that several protocols can quantify this increase in HVR if isocapnia is maintained, regardless of the exact level of Pa(CO(2)). In rats, the isocapnic HVR also increases with chronic hypoxia and this cannot be explained by a non-specific effect of increased ventilatory drive on the HVR. Changes in arterial pH are predicted to increase the HVR during chronic hypoxia in rats but this has not been quantified. Limitations in determining mechanisms of change in the HVR from reflex experiments are discussed. Chronic hypoxia changes some, but not all, indices of ventilatory motor output that are useful for normalization between experiments on anesthetized rats. Finally, ducks also show time-dependent increases in ventilation during chronic hypoxia and birds provide a good experimental model to study reflex interactions. However, reflexes from intrapulmonary CO(2) chemoreceptors can complicate the measurement of changes in the isocapnic HVR during chronic hypoxia in birds.

Author List

Powell FL, Dwinell MR, Aaron EA


Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin


2-s2.0-0034285080   37 Citations

MESH terms used to index this publication - Major topics in bold

Respiratory Mechanics
Species Specificity
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70