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Intracarotid dopamine infusion does not prevent acclimatization to hypoxia. Respir Physiol 1998 Jan;111(1):33-43 PMID: 9496470

Pubmed ID

9496470

Abstract

Ventilatory acclimatization to hypoxia (VAH) is the time-dependent increase in ventilation that occurs during sustained exposure to hypoxia. The mechanism for VAH remains elusive. We sought to determine whether a deficiency in the availability of carotid body dopamine is the mechanism of increased ventilatory responsiveness to hypoxia during VAH in awake goats. This was based on the evidence that dopamine (DA) is primarily an inhibitory neuromodulator of carotid body (CB) function. The hypothesis was tested by intracarotid infusion of DA (5.0 micrograms kg-1 min-1) throughout VAH. VAH was not prevented by DA infusion, failing to support the hypothesis. We conclude that a deficiency in the availability of inhibitory DA release within the CB is probably not responsible for VAH. However, increased ventilatory responses to acute hypoxia after either prolonged DA infusion or hypoxia may have similar CB mechanisms.

Author List

Janssen PL, Dwinell MR, Pizarro J, Bisgard GE

Author

Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin




Scopus

2-s2.0-0031963147   12 Citations

MESH terms used to index this publication - Major topics in bold

Acclimatization
Animals
Carotid Body
Chemoreceptor Cells
Dopamine
Female
Goats
Hypoxia
Infusions, Intra-Arterial
Male
Pulmonary Ventilation
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5