Medical College of Wisconsin
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Carotid body dopaminergic mechanisms are functional after acclimatization to hypoxia in goats. Respir Physiol 1998 Jan;111(1):25-32 PMID: 9496469

Pubmed ID

9496469

Abstract

Ventilatory acclimatization to sustained hypoxia (VASH) is the time-dependent increase in ventilation that occurs during prolonged exposure to hypoxia. We tested the hypothesis that carotid body (CB) dopaminergic mechanisms are down-regulated during VASH, which would allow CB afferent discharge and ventilation to increase beyond the initial response to hypoxia. Domperidone (DOM; 1.0 mg.kg-1) was administered intravenously to block CB dopamine (DA) receptors after VASH was complete in awake goats. DOM caused a significant augmentation of the ventilatory response to hypoxia in acclimatized goats, failing to support the hypothesis. We conclude that inhibitory CB dopaminergic function is not significantly reduced following prolonged hypoxia, and that down-regulation of CB dopaminergic mechanisms may not be involved in VASH in the goat.

Author List

Janssen PL, O'Halloran KD, Pizarro J, Dwinell MR, Bisgard GE

Author

Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin




Scopus

2-s2.0-0031963774   20 Citations

MESH terms used to index this publication - Major topics in bold

Acclimatization
Animals
Carotid Body
Chemoreceptor Cells
Domperidone
Female
Goats
Hypoxia
Male
Pulmonary Ventilation
Receptors, Dopamine D2
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70