Adaptive optics imaging of inherited retinal diseases. Br J Ophthalmol 2018 Aug;102(8):1028-1035
Date
11/17/2017Pubmed ID
29141905Pubmed Central ID
PMC6059037DOI
10.1136/bjophthalmol-2017-311328Scopus ID
2-s2.0-85047410220 (requires institutional sign-in at Scopus site) 61 CitationsAbstract
Adaptive optics (AO) ophthalmoscopy allows for non-invasive retinal phenotyping on a microscopic scale, thereby helping to improve our understanding of retinal diseases. An increasing number of natural history studies and ongoing/planned interventional clinical trials exploit AO ophthalmoscopy both for participant selection, stratification and monitoring treatment safety and efficacy. In this review, we briefly discuss the evolution of AO ophthalmoscopy, recent developments and its application to a broad range of inherited retinal diseases, including Stargardt disease, retinitis pigmentosa and achromatopsia. Finally, we describe the impact of this in vivo microscopic imaging on our understanding of disease pathogenesis, clinical trial design and outcome metrics, while recognising the limitation of the small cohorts reported to date.
Author List
Georgiou M, Kalitzeos A, Patterson EJ, Dubra A, Carroll J, Michaelides MAuthor
Joseph J. Carroll PhD Director, Professor in the Ophthalmology and Visual Sciences department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Eye Diseases, HereditaryHumans
Ophthalmoscopy
Optics and Photonics
Retinal Diseases