Metabolism of dimethylnitrosamine and 1,2-dimethylhydrazine in cultured human bronchi. Cancer Res 1977 Jul;37(7 Pt 1):2309-11
Date
07/01/1977Pubmed ID
861952Scopus ID
2-s2.0-0017744868 (requires institutional sign-in at Scopus site) 19 CitationsAbstract
The metabolic activation of several chemical classes of procarcinogens is being studied in cultured human bronchi. Previous studies have shown that carcinogenic polynuclear aromatic hydrocarbons are metabolically activated by the bronchial epithelium. In the study reported here, dimethylnitrosamine and 1,2-dimethylhydrazine were also found to bind to both cellular DNA and protein. Bronchial DNA was methylated in both the O-6 and N-7 positions of guanine. In addition to polynuclear aromatic hydrocarbons, an aliphatic nitrosamine and a methylhydrazine can now be added to the list of xenobiotic chemical carcinogens metabolized by human bronchus.
Author List
Harris CC, Autrup H, Stoner GD, McDowell EM, Trump BF, Schafer PMESH terms used to index this publication - Major topics in bold
BiotransformationBronchi
Culture Techniques
DNA
Dimethylhydrazines
Dimethylnitrosamine
Guanine
Humans
Hydrazines
Methylation
Mutation
Nitrosamines
Protein Binding