Long-term survival of normal adult human tissues as xenografts in congenitally athymic nude mice. J Natl Cancer Inst 1981 May;66(5):849-58
Date
05/01/1981Pubmed ID
6939929Scopus ID
2-s2.0-0019475961 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
Bronchi, pancreatic ducts, and colons from adult human were maintained as xenografts in congenitally athymic nude N:NIH(S) mice for 715, 145, and 89 days, respectively. After an ischemic crisis and revascularization of the human tissue, the epithelium regenerated to a normal differentiated morphology. The long-term survival of normal adult human epithelial tissues as xenografts provides model systems for the study of the interactions of chemical and/or physical carcinogens with human tissues.
Author List
Valerio MG, Fineman EL, Bowman RL, Harris CC, Stoner GD, Autrup H, Trump BF, McDowell EM, Jones RTMESH terms used to index this publication - Major topics in bold
AnimalsBronchi
Carcinogens
Colon
Disease Models, Animal
Graft Survival
Humans
Mice
Mice, Nude
Neoplasms
Pancreatic Ducts
Pilot Projects
Time Factors
Transplantation, Heterologous
