Medical College of Wisconsin
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The importance of the circadian system & sleep for bone health. Metabolism 2018 07;84:28-43

Date

12/13/2017

Pubmed ID

29229227

Pubmed Central ID

PMC5994176

DOI

10.1016/j.metabol.2017.12.002

Scopus ID

2-s2.0-85040451185   8 Citations

Abstract

Adequate sleep timed appropriately during the circadian night is important for numerous biological processes and systems. New evidence suggests that both sleep timing and duration may be important for optimal bone health as well. This review examines the diurnal variation of bone turnover markers (BTMs) and the importance of circadian clock genes in regulating bone mass. In addition, this review explores the evidence for a link between shift work (and its associated disturbances in sleep duration/quality and circadian alignment) and alterations in bone metabolism and bone health. Finally, we review how commonly used medications and over-the-counter substances (e.g. caffeine, melatonin) complicate the relationship between sleep and circadian disorders and bone health.

Author List

Swanson CM, Kohrt WM, Buxton OM, Everson CA, Wright KP Jr, Orwoll ES, Shea SA

Author

Carol A. Everson PhD Professor in the Medicine department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Bone Density
Bone and Bones
Circadian Clocks
Circadian Rhythm
Health
Humans
Sleep
Sleep Deprivation
jenkins-FCD Prod-400 0f9a74600e4e79798f8fa6f545ea115f3dd948b2