Faculty Collaboration Database

Dissociation between plasma renin and plasma aldosterone induced by dietary glycine hydrochloride. Am J Physiol 1988 Feb;254(2 Pt 1):E187-92

Date

02/11/1988

Pubmed ID

3279801

DOI

10.1152/ajpendo.1988.254.2.E187

Scopus ID

2-s2.0-0023832967 (requires institutional sign-in at Scopus site)   3 Citations

Abstract

We evaluated the effects of selective dietary chloride loading (without sodium) on plasma renin activity (PRA) and plasma aldosterone in the sodium-deprived Sprague-Dawley rat. Three groups of animals were fed one of the following diets for 13 days: 1) low NaCl; 2) high NaCl; or 3) low sodium, high chloride, provided as glycine hydrochloride. Compared with NaCl-deprived animals, PRA and plasma aldosterone were lower (P less than 0.01) in animals fed low sodium high chloride, whereas aldosterone in animals fed glycine hydrochloride was higher (P less than 0.01) than that of NaCl-deprived animals. In contrast, plasma concentrations of corticosterone and 18-hydroxycorticosterone were not increased by selective chloride loading. Glycine chloride-fed animals were acidotic and had elevated plasma concentrations of potassium and ionized calcium. Thus stimulation of aldosterone by selective chloride loading is not related to PRA or ACTH but may be due to a direct effect of acidosis or an indirect effect of acidosis on potassium and/or calcium. Additionally, selective chloride loading appears to stimulate the conversion of 18-hydroxycorticosterone to aldosterone.

Author List

Kotchen TA, Guthrie GP Jr, Boucher LD, Lorenz JN, Ott CE

MESH terms used to index this publication - Major topics in bold

18-Hydroxycorticosterone
Aldosterone
Animals
Corticosterone
Diet
Diet, Sodium-Restricted
Glycine
Male
Rats
Rats, Inbred Strains
Renin