Microbiology. Arresting features of bacterial toxins. Science 2000 Oct 13;290(5490):287-8
Date
02/24/2001Pubmed ID
11183375DOI
10.1126/science.290.5490.287Scopus ID
2-s2.0-0034644599 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Bacteria produce an arsenal of sophisticated toxins that disrupt the normal processes of the host cell, usually by modifying or inactivating host cell proteins. Now, as Coburn and Leong discuss in their Perspective, members of the cytolethal distending toxin (CDT) family have been identified as enzymes that attack DNA (and not protein) within the host cell (Lara-Tejero and Galán). By attacking DNA, perhaps during chromosomal replication, CDTs cause the host cell to halt in G2 phase of the cell cycle.
Author List
Coburn J, Leong JMAuthor
Jenifer Coburn PhD Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBacterial Toxins
Campylobacter jejuni
Cell Death
Cell Division
Cell Nucleus
DNA
DNA Damage
DNA Replication
Deoxyribonuclease I
Epithelial Cells
G2 Phase
Genes, Bacterial
Lymphocytes
Monocytes
Mutation
Sequence Homology, Amino Acid