Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

ADP-ribosylation of p21ras and related proteins by Pseudomonas aeruginosa exoenzyme S. Infect Immun 1991 Nov;59(11):4259-62 PMID: 1937783 PMCID: PMC259026

Pubmed ID

1937783

Abstract

Pseudomonas aeruginosa exoenzyme S ADP-ribosylates p21ras and several related proteins. ADP-ribosylation of p21ras does not alter interactions with guanine nucleotides. The ras-related GTP-binding proteins, including Rab3, Rab4, Ral, Rap1A, and Rap2, are also substrates; given these results, we propose a model for the role of exoenzyme S in pathogenesis.

Author List

Coburn J, Gill DM

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0025925037   85 Citations

MESH terms used to index this publication - Major topics in bold

ADP Ribose Transferases
Bacterial Toxins
GTP-Binding Proteins
GTPase-Activating Proteins
Guanine Nucleotides
In Vitro Techniques
Poly(ADP-ribose) Polymerases
Proteins
Proto-Oncogene Proteins p21(ras)
Pseudomonas aeruginosa
ras GTPase-Activating Proteins
jenkins-FCD Prod-321 98992d628744e349846c2f62ac68f241d7e1ea70