Faculty Collaboration Database

Morphine Pharmacokinetics in Children With Down Syndrome Following Cardiac Surgery. Pediatr Crit Care Med 2018 May;19(5):459-467

Date

03/17/2018

Pubmed ID

29547456

DOI

10.1097/PCC.0000000000001537

Scopus ID

2-s2.0-85051859139 (requires institutional sign-in at Scopus site)   4 Citations

Abstract

OBJECTIVES: To assess if morphine pharmacokinetics are different in children with Down syndrome when compared with children without Down syndrome.

DESIGN: Prospective single-center study including subjects with Down syndrome undergoing cardiac surgery (neonate to 18 yr old) matched by age and cardiac lesion with non-Down syndrome controls. Subjects were placed on a postoperative morphine infusion that was adjusted as clinically necessary, and blood was sampled to measure morphine and its metabolites concentrations. Morphine bolus dosing was used as needed, and total dose was tracked. Infusions were continued for 24 hours or until patients were extubated, whichever came first. Postinfusion, blood samples were continued for 24 hours for further evaluation of kinetics. If patients continued to require opioid, a nonmorphine alternative was used. Morphine concentrations were determined using a unique validated liquid chromatography tandem-mass spectrometry assay using dried blood spotting as opposed to large whole blood samples. Morphine concentration versus time data was modeled using population pharmacokinetics.

SETTING: A 16-bed cardiac ICU at an university-affiliated hospital.

PATIENTS: Forty-two patients (20 Down syndrome, 22 controls) were enrolled.

INTERVENTIONS: None.

MEASUREMENTS AND MAIN RESULTS: The pharmacokinetics of morphine in pediatric patients with and without Down syndrome following cardiac surgery were analyzed. No significant difference was found in the patient characteristics or variables assessed including morphine total dose or time on infusion. Time mechanically ventilated was longer in children with Down syndrome, and regarding morphine pharmacokinetics, the covariates analyzed were age, weight, presence of Down syndrome, and gender. Only age was found to be significant.

CONCLUSIONS: This study did not detect a significant difference in morphine pharmacokinetics between Down syndrome and non-Down syndrome children with congenital heart disease.

Author List

Goot BH, Kaufman J, Pan Z, Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, Zuk J, da Cruz EM

Author

Ben Goot MD Associate Professor in the Pediatrics department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adolescent
Analgesics, Opioid
Cardiac Surgical Procedures
Case-Control Studies
Child
Child, Preschool
Down Syndrome
Female
Follow-Up Studies
Heart Defects, Congenital
Humans
Infant
Infant, Newborn
Infusions, Intravenous
Male
Morphine
Pain, Postoperative
Prospective Studies