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The emergence of Lyme disease. J Clin Invest 2004 Apr;113(8):1093-101 PMID: 15085185 PMCID: PMC385417

Pubmed ID

15085185

Abstract

Since its identification nearly 30 years ago, Lyme disease has continued to spread, and there have been increasing numbers of cases in the northeastern and north central US. The Lyme disease agent, Borrelia burgdorferi, causes infection by migration through tissues, adhesion to host cells, and evasion of immune clearance. Both innate and adaptive immune responses, especially macrophage- and antibody-mediated killing, are required for optimal control of the infection and spirochetal eradication. Ecological conditions favorable to the disease, and the challenge of prevention, predict that Lyme disease will be a continuing public health concern.

Author List

Steere AC, Coburn J, Glickstein L

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-2142660806   507 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Humans
Lyme Disease
Ticks
jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1