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Gallbladder carcinoma: An analysis of the national cancer data base to examine hispanic influence. J Surg Oncol 2018 Jun;117(8):1664-1671

Date

05/02/2018

Pubmed ID

29714811

DOI

10.1002/jso.25050

Scopus ID

2-s2.0-85046125870   1 Citation

Abstract

BACKGROUND: Gallbladder cancer (GBC) is a lethal disease with high incidence among Hispanics. Overall survival (OS) among races/ethnicities has not been described using the most recent National Cancer Database. This study hypothesized that prognosis is worse for Hispanics compared to similar non-Hispanic populations.

METHODS: Patients with GBC were identified from the National Cancer Database and categorized as White, Black, Hispanic, and Other. Descriptive statistics, OS, and Cox regression were examined.

RESULTS: The study identified 12 952 patients. Median age was 71 years and 68.8% were female. The study characterized 69.8% White, 13.9% Black, 11.0% Hispanic, and 5.4% other patients. A 5-year OS curves differed, with survival highest in Hispanic patients (27% vs 23% Other, 18% White, and 17% Black, P < 0.001). Hispanics presented at younger ages (67 vs 72 years, P < 0.001), were more likely to be uninsured (17.3% vs 3.9% P < 0.001), had lower income (P < 0.001), and education levels (P < 0.001) compared to Whites. Following multivariable modeling, treatment at an academic facility (HR 0.90, 95%CI 0.84-0.97) and year of diagnosis (HR 0.90, 95%CI 0.88-0.92) related to survival. Hispanic ethnicity did not show significance (P = 0.207).

DISCUSSION: Hispanic ethnicity exhibits the highest OS for GBC, but after adjusting for covariates, this influence is not significant.

Author List

Liu C, Berger NG, Rein L, Tarima S, Clarke C, Mogal H, Christians KK, Tsai S, Gamblin TC

Authors

Kathleen K. Christians MD Professor in the Surgery department at Medical College of Wisconsin
Callisia N. Clarke MD Assistant Professor in the Surgery department at Medical College of Wisconsin
Thomas Clark Gamblin MD Chief, Professor in the Surgery department at Medical College of Wisconsin
Harveshp Mogal MD Assistant Professor in the Surgery department at Medical College of Wisconsin
Sergey S. Tarima PhD Associate Professor in the Institute for Health and Equity department at Medical College of Wisconsin
Susan Tsai MD Associate Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Academic Medical Centers
African Americans
Age Factors
Aged
Cohort Studies
Databases, Factual
Educational Status
European Continental Ancestry Group
Female
Gallbladder Neoplasms
Hispanic Americans
Humans
Income
Male
Medically Uninsured
Prognosis
Retrospective Studies
Sex Factors
Survival Rate
United States
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc