Faculty Collaboration Database

Videoradiographic, manometric, and electromyographic analysis of canine upper esophageal sphincter. Am J Physiol 1991 Jun;260(6 Pt 1):G911-9

Date

06/01/1991

Pubmed ID

2058678

DOI

10.1152/ajpgi.1991.260.6.G911

Scopus ID

2-s2.0-0025808210 (requires institutional sign-in at Scopus site)   69 Citations

Abstract

We assessed upper esophageal sphincter (UES) function in dogs by concurrent recording of cricopharyngeal electromyographic (EMG) activity, intraluminal pressure, and dimensional changes of the pharyngoesophageal junction at rest and during swallowing. Radial and axial pressure profiles of the UES were determined by continuous pull-through manometry. EMG activity of the cricopharyngeus and thyropharyngeus muscles were correlated with UES pressure under static conditions. We also quantified the temporal relationships among EMG activity of the cricopharyngeus, UES pressure, and pharyngoesophageal junction dimensional changes during swallowing of 2, 4, and 6 ml of barium. When the dogs were prone, the anterior and posterior UES pressures were about twice the lateral pressures and the axial length of the UES was approximately 4 cm. All radial pressures equalized to approximately 20 mmHg when the dogs lay on their sides. The peak pressure zone of the UES corresponded closely with the level of the cricopharyngeal electrode, and resting UES pressure correlated closely with cricopharyngeal but not thyropharyngeal EMG activity. During swallowing, the cricopharyngeus relaxed approximately 200 ms before UES opening and 100 ms before UES relaxation. Superior movement of the hyoid and the larynx was associated temporally with UES relaxation, while anterior movement was associated with UES opening. Increases in bolus volume significantly increased maximal sagittal UES diameter during UES opening but did not alter temporal changes in UES function.(ABSTRACT TRUNCATED AT 250 WORDS)

Author List

Lang IM, Dantas RO, Cook IJ, Dodds WJ

Author

Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Deglutition
Dogs
Electromyography
Esophagus
Manometry
Muscle Relaxation
Muscle, Smooth
Pharynx
Pressure
Radiography
Video Recording