Faculty Collaboration Database

Prenatal counseling and parental decision-making following a fetal diagnosis of trisomy 13 or 18. J Perinatol 2018 Jul;38(7):788-796

Date

05/10/2018

Pubmed ID

29740195

DOI

10.1038/s41372-018-0107-x

Scopus ID

2-s2.0-85046694812 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

OBJECTIVES: To evaluate parental decisions following a prenatal diagnosis of trisomy 13 (T13) or trisomy 18 (T18), prenatal counseling received, and pregnancy outcomes.

STUDY DESIGN: Single-center, retrospective cohort study of families with a prenatal diagnosis of T13 or T18 from 2000 to 2016.

RESULTS: Out of 152 pregnancies, 55% were terminated. Twenty percent chose induction with palliative care, 20% chose expectant management, 2% chose full interventions, and 3% were lost to follow-up. Counseling was based on initial parental goals, but most women were given options besides termination. Women who chose expectant management had a live birth in 50% of the cases. Women who chose neonatal interventions had a live birth in 100% of the cases, but there were no long-term survivors.

CONCLUSIONS: The majority of women who continue their pregnancy after a fetal diagnosis of T13 or T18 desire expectant management with palliative care. A live birth can be expected at least half of the time.

Author List

Winn P, Acharya K, Peterson E, Leuthner S

Authors

Krishna Kartikey Acharya MBBS Associate Professor in the Pediatrics department at Medical College of Wisconsin
Steven R. Leuthner MD Professor in the Pediatrics department at Medical College of Wisconsin
Erika Peterson MD Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Cohort Studies
Decision Making
Directive Counseling
Female
Humans
Infant, Newborn
Live Birth
Male
Parents
Pregnancy
Pregnancy Outcome
Prenatal Care
Prenatal Diagnosis
Prognosis
Retrospective Studies
Survival Analysis
Trisomy 13 Syndrome
Trisomy 18 Syndrome